Saline, MI, United States

29 Geographical Superlatives That Will Change How You See the World

From the world’s tallest peaks to its deepest lakes and beyond

2024-12-17 12:59

Management and prognostic prediction of pyogenic liver abscess in a Chinese tertiary hospital: Percutaneous needle aspiration vs catheter drainage

Pyogenic liver abscess (PLA) is a serious infectious disease with high mortality. The aim of our study was to compare the efficacy of percutaneous needle aspiration (PNA) and percutaneous catheter drainage (PCD) for PLA and to assess risk factors for unfavora…

2024-12-16 14:00

Activation of the tick Toll pathway to control infection of Ixodes ricinus by the apicomplexan parasite Babesia microti

Author summary Ticks are important parasites of humans and animals worldwide. They act as vectors of numerous serious diseases such as Lyme disease, tick-borne encephalitis, rickettsiosis, babesiosis, and theileriosis. The innate immune system of ticks plays …

2024-12-16 14:00

The conserved noncoding RNA ModT coordinates growth and virulence in Clostridioides difficile

Bacterial non-coding RNAs influence various cellular functions and often have complex tertiary structures. This study characterizes ModT, a conserved ncRNA found in 2,500 bacterial species, found to regulate growth transition and sporulation in Clostridioides…

2024-12-13 14:00

What Makes Hospitals So Deadly and How Can We Fix It?

During COVID-19, we witnessed something previously unimaginable. A national emergency hospitalized thousands of Americans, where they were cut off from their loved ones and inevitably died. It soon became clear that the hospital protocols did not work, but re…

2024-12-13 00:00

Genetic inactivation of zinc transporter SLC39A5 improves liver function and hyperglycemia in obesogenic settings

Recent studies have revealed a role for zinc in insulin secretion and glucose homeostasis. Randomized placebo-controlled zinc supplementation trials have demonstrated improved glycemic traits in patients with type II diabetes (T2D). Moreover, rare loss-of-fun…

2024-12-13 00:00

Georgia’s Pro-Europe Protesters Are Facing Down Police Violence

Tbilisi’s streets have become the site of nightly conflicts.

2024-12-12 21:14

Assessment of changes in intra-abdominal pressure and cardiac output induced by liver compression in healthy anesthetized spontaneously breathing dogs

Objective Liver compression (LC) has been proposed to predict fluid responsiveness in human pediatric patients. Because the evaluation of fluid responsiveness through LC depends on the mechanism of increased intra-abdominal pressure (IAP), understanding the i…

2024-12-12 14:00

Structure of the Pseudomonas aeruginosa PAO1 Type IV pilus

Author summary Pseudomonas aeruginosa is an important human pathogen that poses a critical problem in hospital settings, causing widespread antibiotic-resistant infections. P. aeruginosa evades antibiotic treatments by forming biofilms, i.e. surface-attached,…

2024-12-12 14:00

Leptospira seroprevalence and associated risk factors among slaughterhouse workers in Western Bahr El Ghazal State, South Sudan

Author summary Leptospirosis is a re-emerging zoonotic disease affecting people who work closely with animals. In Africa, livestock contact is thought to be a potential source of human Leptospira exposure. This study examined occupational exposure among slaug…

2024-12-11 14:00