Saline, MI, United States

Hepatitis B virus hijacks MRE11–RAD50–NBS1 complex to form its minichromosome

Author summary Chronic hepatitis B virus (HBV) infection poses a major challenge due to the persistence of covalently closed circular DNA (cccDNA), a key barrier to effective treatment. Our study investigates the formation of cccDNA from the viral relaxed cir…

2025-01-03 14:00

Psychiatry’s Latest Insane Magic-Bullet Treatment for Depression: Why Ketamine?

Clinics offering ketamine infusions and injections for “treatment-resistant depression” are today claiming 24-48 hours remission, and ketamine is also being marketed for post-traumatic stress disorder (PTSD), obsessive-compulsive disorder, bipolar disorder, a…

2025-01-03 07:05

How many counties in Kansas?

How Many Counties in Kansas? Kansas is a state located in the Midwestern United States, known for its rich history, […] The post How many counties in Kansas? appeared first on Life Sciences World.

2025-01-02 14:11

Obesity-induced activation of NADPH oxidase 2 prolongs cardiac repolarization via inhibiting K+ currents

Obesity is associated with abnormal repolarization manifested by QT interval prolongation, and oxidative stress is an important link between obesity and arrhythmias. However, the underlying electrophysiological and molecular mechanisms remain unclear. The aim…

2024-12-31 14:00

Randomized, observer-blind, controlled Phase 1 study of the safety and immunogenicity of the Na-GST-1/Alhydrogel hookworm vaccine with or without a CpG ODN adjuvant in hookworm-naïve adults

Author summary Infection caused by Necator americanus is a major neglected tropical disease with significant associated morbidity. New tools, including vaccines, are needed due to the inadequacy of current control strategies. N. americanus Glutathione-S-Trans…

2024-12-30 14:00

MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi

Author summary Lyme disease is the most commonly reported arthropod-borne illness in the US, Europe, and Asia. The causative agent of Lyme disease, Borrelia or Borreliella burgdorferi, is maintained in an enzootic cycle involving arthropod vectors (Ixodes tic…

2024-12-30 14:00

Gaslighting RFK Jr.’s role in the deadly Samoan measles outbreak

One of many shameful incidents in the life of antivax activist Robert F. Kennedy Jr. was his promotion of anti-MMR fear mongering during a measles epidemic in Samoa. Now that he could become HHS Secretary, his apologists are frantically trying to gaslight you…

2024-12-30 08:00

Potential use of salivary TNF-α as a vaccine-induced pain biomarker in people with cerebral palsy and communication disorders

Background Pain in people with cerebral palsy (CP) has been classically underestimated and poorly treated, particularly in individuals with impaired communication skills. Objective To analyze changes in different salivary metabolites and pain behavior scale…

2024-12-27 14:00

Estuarine dispersal of an invasive Holarctic predator (Esox lucius) confirmed in North America

The capacity for a non-native species to become invasive largely hinges on existing dispersal capacity or adaptation of dispersal in new environments. Here we provide early evidence that invasive Northern Pike (Esox lucius), a Holarctic freshwater top predato…

2024-12-27 14:00

Enriched microbial consortia from natural environments reveal core groups of microbial taxa able to degrade terephthalate and terphthalamide

Millions of tons of polyethylene terephthalate (PET) are produced each year, however only ~30% of PET is currently recycled in the United States. Improvement of PET recycling and upcycling practices is an area of ongoing research. One method for PET upcycling…

2024-12-27 14:00