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A novel esterase regulates Klebsiella pneumoniae hypermucoviscosity and virulence
Author summary Klebsiella pneumoniae is an antibiotic-resistant pathogen known for its virulence factor, hypermucoviscosity (HMV), which relies on the production of capsular polysaccharides (CPS). This study highlights the roles of two key enzymes: KpACE, an …
2024-10-31 14:00Equine bone marrow-derived mesenchymal stromal cells reduce established S. aureus and E. coli biofilm matrix in vitro
Biofilms reduce antibiotic efficacy and lead to complications and mortality in human and equine patients with orthopedic infections. Equine bone marrow-derived mesenchymal stromal cells (MSC) kill planktonic bacteria and prevent biofilm formation, but their a…
2024-10-31 14:00Skeptical Science New Research for Week #44 2024
Open access notables Communicating the most accurate and reliable science on climate change to society: A survey of editors from the Intergovernmental Panel on Climate Change, Molina & Abadal Abadal, Geoscience Communication: This study focuses on the perspe…
2024-10-31 07:39Femasys Inc. Updates Investor Presentation in Recent 8-K Filing
Femasys Inc. (NASDAQ: FEMY) revealed in its recent 8-K filing on October 29, 2024, that the company has updated its slide presentation, now available on its official website. Included as Exhibit 99.1 in the filing, the updated presentation is intended for use…
2024-10-31 06:12UN Reports Surge in Killings and Police Executions in Haiti
Surging gang control in Port-au-Prince has seen violent crimes and murders rise by 30 percent since July.
2024-10-30 22:07Exploring the photosensitizing potential of Nanoliposome Loaded Improved Toluidine Blue O (NLITBO) Against Streptococcus mutans: An in-vitro feasibility study
Background Streptococcus mutans is a major contributor to dental caries due to its ability to produce acid and survive in biofilms. Microbial resistance towards common antimicrobial agents like chlorhexidine and triclosan has shifted the research towards anti…
2024-10-30 14:00Live Around the Planet: Wednesday October 30th
UPPESTDATE! Thank you for all your questions. If you missed the live broadcast, the action replay can be heard in full here. UPPERDATE! We're live now, so let's have at it! UPDATE! We'll be going live in about fifteen minutes, so do get ready to fire off
2024-10-30 14:00Morphine self-administration is inhibited by the antioxidant N‐acetylcysteine and the anti-inflammatory ibudilast; an effect enhanced by their co-administration
Background The treatment of opioid addiction mainly involves the medical administration of methadone or other opioids, aimed at gradually reducing dependence and, consequently, the need for illicit opioid procurement. Thus, initiating opioid maintenance thera…
2024-10-29 14:00Multi-omics analyses of Bacillus amyloliquefaciens treated mice infected with Schistosoma japonicum reveal dynamics change of intestinal microbiome and its associations with host metabolism
Author summary Schistosomiasis, which seriously threatens human health, is the world’s second largest tropical disease caused by schistosome infection. Praziquantel has many problems such as side effects and drug resistance, so it is urgent to develop new pre…
2024-10-28 14:00MICU2 up-regulation enhances tumor aggressiveness and metabolic reprogramming during colorectal cancer development
Upregulation of the mitochondrial calcium uniporter (MCU) has been shown to facilitate colorectal cancer cell growth, but the contributions of MCU-regulatory proteins are not known. These authors show that MICU2 ensures metabolic flexibility between anaerobic…
2024-10-28 14:00