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Delineating the functional activity of antibodies with cross-reactivity to SARS-CoV-2, SARS-CoV-1 and related sarbecoviruses

Author summary There is a large collection of sarbecoviruses related to SARS-CoV-2 circulating in animal reservoirs with the potential to spillover into humans. Neutralizing antibodies have the potential to protect against infection, although viral escape is …

2024-10-28 14:00
Molecular characterization of PANoptosis-related genes in chronic kidney disease

Chronic kidney disease (CKD) is characterized by fibrosis and inflammation in renal tissues. Several types of cell death have been implicated in CKD onset and progression. Unlike traditional forms of cell death, PANoptosis is characterized by the crosstalk am…

2024-10-28 14:00
Characteristic disease defects in circulating endothelial cells isolated from patients with pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary arterial pressures that can lead to right heart failure and death. No cure exists for this disease, but therapeutic advancements have extended its median surviv…

2024-10-28 14:00
Monitoring of activity-driven trafficking of endogenous synaptic proteins through proximity labeling

The fast dynamics of synaptic vesicle release present a challenge for the quantification of synaptic protein translocation during neuronal activity. This study presents a method for quantifying the translocation of endogenous neuronal proteins to the synaptic…

2024-10-28 14:00
Impact of tidal fluctuations on bacterial community structure in Wuyuan Bay: A comparative analysis of waters inside and outside the tidal barrage

The tidal barrage at Wuyuan Bay effectively mitigated the odor from the tidal flat during ebb tide, however, its effect on bacterial community structure in waters are still unclear. In this study, high-throughput sequencing was used to analyze the structure o…

2024-10-25 14:00
Locally Acquired (Autochthonous) Mosquito-Transmitted Plasmodium vivax Malaria - Saline County, Arkansas, September 2023

This report describes the public health response to 10 cases of locally acquired mosquito-borne malaria in the U.S.

2024-10-24 17:00
Individualistic reward-seeking strategies that predict response to nicotine emerge among isogenic male mice living in a micro-society

What are the neurophysiological mechanisms of the relationship between individual traits and nicotine use? This study uses a semi-natural and social environment for mice and revealed neurophysiological markers within the dopamine system that were apparent upo…

2024-10-24 14:00
Procyon Corporation Faces Delays in Form 10-K Filing Due to Hurricanes Helene and Milton – 8-K SEC Filing Report

Procyon Corporation, a Colorado-based company (OTCMKTS:PCYN), has recently experienced unforeseen challenges leading to delays in the filing of its Form 10-K for the fiscal year ended June 30, 2024. As detailed in their 8-K SEC filing on October 22, 2024, the…

2024-10-24 06:05
Transcriptomic signatures of WNT-driven pathways and granulosa cell-oocyte interactions during primordial follicle activation

Primordial follicle activation (PFA) is a pivotal event in female reproductive biology, coordinating the transition from quiescent to growing follicles. This study employed comprehensive single-cell RNA sequencing to gain insights into the detailed regulatory…

2024-10-23 14:00
Dogs May Be Entering A New Phase Of Evolution Due To Modern Human Life, According To Scientists

Scientists discover dogs may be entering a new phase of evolution. The post Dogs May Be Entering A New Phase Of Evolution Due To Modern Human Life, According To Scientists first appeared on Bored Panda.

2024-10-22 14:10