Saline, MI, United States

Melioidosis in goats at a single Australian farm was caused by multiple diverse lineages of Burkholderia pseudomallei present in soil

Author summary We studied genomic diversity in the environmental bacterial pathogen, Burkholderia pseudomallei, which caused the disease melioidosis in goats at a small farm in northern Australia. By comparing genomes from 92 B. pseudomallei isolates from goa…

2024-12-19 14:00

Connectome-based prediction of functional impairment in experimental stroke models

Experimental rat models of stroke and hemorrhage are important tools to investigate cerebrovascular disease pathophysiology mechanisms, yet how significant patterns of functional impairment induced in various models of stroke are related to changes in connect…

2024-12-19 14:00

U.S. Water Woes – Northeast

Megalopolises need fresh clean drinking water – a lot of it.  NY City needs a billion gallons a day. NY City ‘steals’ much of that water from the Catskills – at least in the opinion of the people that live there and are subject to arbitrary rules made and en…

2024-12-18 06:00

Trichuriasis in Human Patients from Côte d’Ivoire Caused by Novel Species Trichuris incognita with Low Sensitivity to Albendazole/Ivermectin Combination Treatment

Trichuriasis in Human Patients from Côte d’Ivoire

2024-12-18 05:00

IRX-related homeobox gene MKX is a novel oncogene in acute myeloid leukemia

Homeobox genes encode transcription factors which organize differentiation processes in all tissue types including the hematopoietic compartment. Recently, we have reported physiological expression of TALE-class homeobox gene IRX1 in early myelopoiesis restri…

2024-12-17 14:00

Thermosensory behaviors of the free-living life stages of Strongyloides species support parasitism in tropical environments

Author summary Soil-transmitted parasitic nematodes infect over 1 billion people and are a major source of neglected disease, particularly in the world’s most resource-limited communities. For most parasitic nematode species, reproductive adults exclusively r…

2024-12-17 14:00

A previously unidentified circRNA inhibits virus replication by regulating the miR-24-3p/KEAP1 axis

Author summary As an important epidemic affecting pig farming, Pseudorabies (PR) outbreaks in China since 2011, caused by variant Pseudorabies virus (PRV) (genotype II) in Bartha-K61-vaccinated pigs, have resulted in considerable economic losses. In addition,…

2024-12-17 14:00

Genome alteration of Leishmania orientalis under Amphotericin B inhibiting conditions

Author summary Leishmaniasis is a neglected tropical disease caused by parasites of the Leishmania genus, and treatments often rely on drugs like Amphotericin B (AmB). This study focuses on Leishmania orientalis, a newly recognized species, to better understa…

2024-12-17 14:00

Loss of STAT3 in osteoblasts has detrimental and sexually dimorphic effects on skeletal development

Studies with genetically modified mice have implicated the transcriptional regulator STAT3 as a key modulator of bone development. STAT3-OKO knockout mouse lines were generated in two genetic backgrounds, pure C57BL/6 (STAT3-OKO-BL) and mixed C57BL/6, CD1 (ST…

2024-12-17 14:00

Association between in situ ventilation and human-generated aerosol exposure in meatpacking plants during the COVID-19 pandemic

During the COVID-19 pandemic, meatpacking workers were disproportionately affected by disease. Large outbreaks at meatpacking facilities resulted in loss of life and threatened the well-being of workers across the globe. Much work was done throughout the pand…

2024-12-17 14:00