Saline, MI, United States

Ghrelin is involved in regulating the progression of Echinococcus Granulosus-infected liver lesions through suppression of immunoinflammation and fibrosis

Author summary There is evidence that Echinococcus granulosus (E.g) is susceptible to immune escape and tolerance when host expression of immunoinflammation and fibrosis is suppressed, accelerating the progression of hepatic cystic Echinococcosis (CE). Ghreli…

2024-10-22 14:00

Free long-chain fatty acids trigger early postembryonic development in starved Caenorhabditis elegans by suppressing mTORC1

Macronutrients are known to provide biomatter and energy to postembryonic development in animals. This study shows that free fatty acids act as a primary nutrient signal to trigger early development in C. elegans, expanding the traditional function of specifi…

2024-10-22 14:00

LD-transpeptidation is crucial for fitness and polar growth in Agrobacterium tumefaciens

Author summary Peptidoglycan (PG) is essential for bacterial cell wall integrity. While most bacteria use penicillin binding proteins (PBPs) for crosslinking, some also employ LD-transpeptidases (LDTs); however, the essentiality and functions of LDTs remain p…

2024-10-21 14:00

Recovery after human bone marrow mesenchymal stem cells (hBM-MSCs)-derived extracellular vesicles (EVs) treatment in post-MCAO rats requires repeated handling

Rehabilitation is the only current intervention that improves sensorimotor function in ischemic stroke patients, similar to task-specific intensive training in animal models of stroke. Bone marrow mesenchymal stem cells (BM-MSCs)-derived extracellular vesicle…

2024-10-21 14:00

Linkage-specific ubiquitin binding interfaces modulate the activity of the chlamydial deubiquitinase Cdu1 towards poly-ubiquitin substrates

Author summary As a post-translational modification ubiquitination plays key roles in virtually all cellular processes and is also involved in the host immune response upon infection with intracellular pathogens. Chlamydia trachomatis secretes the two deubiqu…

2024-10-21 14:00

America's first big plant for capturing carbon dioxide is leaking

This story was originally published by Grist. Sign up for Grist’s weekly newsletter here. This coverage is made possible through a partnership between Grist and WBEZ, a public radio station serving the Chicago metropolitan region.Read more...

2024-10-21 12:17

The nation’s first commercial carbon sequestration plant is in Illinois. It leaks.

Citizens in Decatur, Illinois, are alarmed to hear there were two leaks in the CCS plant run by Archer-Daniel-Midlands.

2024-10-21 08:45

US Hospitals Face Critical IV Fluid Shortage After Baxter Facility Shuts Down Due To Hurricane Helene

The United States is facing a significant shortage of intravenous (IV) fluids, including saline and dextrose solutions, exacerbated by damage to Baxter International (NYSE:BAX) plants in North Carolina due to Hurricane Helene. These essential fluids, already …

2024-10-18 14:50

Aging-induced dysbiosis worsens sepsis severity but is attenuated by probiotics in D-galactose-administered mice with cecal ligation and puncture model

Introduction Despite the well-established effects of aging on brain function and gut dysbiosis (an imbalance in gut microbiota), the influence of aging on sepsis-associated encephalopathy (SAE) and the role of probiotics in this context remain less understood…

2024-10-18 14:00

Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome

Plants use NLR immune receptors, which often require downstream "helper" NLRs, for pathogen defense. This study identifies and structurally characterizes the mechanisms of NLR activation, showing that a helper NLR, NRC2, transitions from an autoinhibited homo…

2024-10-18 14:00