Billerica, MA, United States

E Ink Wins Manufacturer of the Year at the 9th Annual Massachusetts Manufacturing Awards Ceremony

E Ink recognized by the Commonwealth’s Legislative Manufacturing Caucus as Manufacturer of the Year at the 9th Annual Massachusetts Manufacturing Awards

2024-09-25 18:00

Distribution of MRI-derived T2 values as a biomarker for in vivo rapid screening of phenotype severity in mdx mice

Background The pathology in Duchenne muscular dystrophy (DMD) is characterized by degenerating muscle fibers, inflammation, fibro-fatty infiltrate, and edema, and these pathological processes replace normal healthy muscle tissue. The mdx mouse model is one of…

2024-09-19 14:00

Targeting ferroptosis with the lipoxygenase inhibitor PTC-041 as a therapeutic strategy for the treatment of Parkinson’s disease

Parkinson’s disease is the second most common neurodegenerative disorder, affecting nearly 10 million people worldwide. Ferroptosis, a recently identified form of regulated cell death characterized by 15-lipoxygenase-mediated hydroperoxidation of membrane lip…

2024-09-18 14:00

Curcumin alleviates osteoarthritis in mice by suppressing osteoclastogenesis in subchondral bone via inhibiting NF-κB/JNK signaling pathway

This study explored the mechanism of curcumin (CUR) suppressing osteoclastogenesis and evaluated its effects on osteoarthritis (OA) mouse. Bone marrow-derived macrophages were isolated as osteoclast precursors. In the presence or absence of CUR, cell prolifer…

2024-09-05 14:00

Stenotrophomonas maltophilia uses a c-di-GMP module to sense the mammalian body temperature during infection

Author summary The body temperature of mammals, typically around 37°C, serves as an important host-derived signal for pathogens thriving at substantially lower temperatures. The ability to detect and respond to this host-derived temperature signal is essentia…

2024-09-04 14:00