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10 Intriguing Stories about the First Reich’s Antichrist
He was called “Stupor Mundi,” the astonishment of the world. Frederick II of Hohenstaufen remains as controversial now as he was when he was emperor of the First Reich, the Holy Roman Empire. He was painted larger than life by his contemporaries, friends, and…
2024-08-11 07:01Rapid and efficient generation of mature retinal organoids derived from human pluripotent stem cells via optimized pharmacological modulation of Sonic hedgehog, activin A, and retinoic acid signal transduction
Human retinal organoids have become indispensable tools for retinal disease modeling and drug screening. Despite its versatile applications, the long timeframe for their differentiation and maturation limits the throughput of such research. Here, we successfu…
2024-08-09 14:00Merkel cell polyomavirus small tumor antigen contributes to immune evasion by interfering with type I interferon signaling
Author summary Merkel cell polyomavirus (MCPyV) is the only human polyomavirus that causes cancer in humans. As with all human polyomaviruses, the available infection models are limited. Thus, many processes such as the host response to infection and its regu…
2024-08-07 14:00Induction of cell death by sodium hexachloroplatinate (IV) in the HEI-OC1 cell line, primary rat spiral ganglion cells and rat organ of Corti explants
Although cochlear implants have become a well-established method for patients with sensory neural hearing loss, clinical results indicate that in some cases, corrosion of electrode contacts leads to high impedance that interferes with successful stimulation o…
2024-07-26 14:00Use of the perceptual point-spread function to assess dysphotopsias
Nowadays many patients are choosing EDOF or multifocal lenses for replacement of natural lens in cataract surgery. This can result in issues such as presence of dysphotopsias, namely halo and glare. In this work, we propose a new perimetry method to describe …
2024-07-19 14:00Octopamine is required for successful reproduction in the classical insect model, Rhodnius prolixus
In insects, biogenic amines function as neurotransmitters, neuromodulators, and neurohormones, influencing various behaviors, including those related to reproduction such as response to sex pheromones, oogenesis, oviposition, courtship, and mating. Octopamine…
2024-07-12 14:00One of These Photographers Will Win the 2024 Leica Oskar Barnack Award
Leica has announced the 12 photographers shortlisted for the prestigious Leica Oskar Barnack Award (LOBA). [Read More]
2024-07-12 13:00Aberrant activation of hippocampal astrocytes causes neuroinflammation and cognitive decline in mice
LCN2 is an inflammatory mediator that is upregulated under diverse neuropathological conditions. This study shows that repetitive and sustained stimulation of hippocampal astrocytes induces reactive astrogliosis and subsequent LCN2 release, triggering neuroin…
2024-07-11 14:00A rare collection of 7 prototype Leica M cameras by Ralph Gibson is listed for $250,000
Leica Store Lisse is selling a rare collection of 7 prototype Leica M cameras by Ralph Gibson for $250,000 on eBay (check also their other listings). Ralph Gibson’s Leica collection Ralph Nelson’ Leica M4 cameras kit obtained by Leica Store Lisse Ebay listing…
2024-07-11 01:37